Pharmacokinetic changes in critical illness.

Common Drug Interactions Leading to Adverse Drug Events in the ICU: Management and Pharmacokinetic Considerations

Critically ill patients, given the nature and extent of their critical illness, frequently receive complex multidrug regimens. Organ dysfunction and polypharmacy potentially can lead to adverse drug interplay and an adverse event. Drug interactions may be pharmacokinetic or pharmacodynamic. A pharmacokinetic interaction arises when one drug alters the absorption, distribution, metabolism, or el...

Pharmacokinetic issues for antibiotics in the critically ill patient.

OBJECTIVE To discuss the altered pharmacokinetic properties of selected antibiotics in critically ill patients and to develop basic dose adjustment principles for this patient population. DATA SOURCES PubMed, EMBASE, and the Cochrane-Controlled Trial Register. STUDY SELECTION Relevant papers that reported pharmacokinetics of selected antibiotic classes in critically ill patients and antibio...

Pharmacokinetic (PK) Characteristics in Critically Ill Patients

Optimal Aminoglycoside Therapy Following the Sepsis: How Much Is Too Much?

Severe sepsis and septic shock are major problems as the result of high rates morbidity andmortality in intensive care units (ICUs). In the presence of septic shock, each hour of delay inthe administration of effective antibiotics is associated with a measurable increase in mortality.Aminoglycosides are effective broad-spectrum antibiotics that are commonly used in ICUs forthe treatment of life...

Optimal Aminoglycoside Therapy Following the Sepsis: How Much Is Too Much?

Severe sepsis and septic shock are major problems as the result of high rates morbidity andmortality in intensive care units (ICUs). In the presence of septic shock, each hour of delay inthe administration of effective antibiotics is associated with a measurable increase in mortality.Aminoglycosides are effective broad-spectrum antibiotics that are commonly used in ICUs forthe treatment of life...